Recombinant Human Ovarian cancer G-protein coupled receptor 1 (GPR68), Truncated

Uniprot Id

Q15743

Target Species

Human

Target Name

GPR68

Target Full Name

Ovarian cancer G-protein coupled receptor 1

Target Function

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.

Target Involvement

Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

Target Synonyms

GPR68; OGR1; Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor

Target Background

The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta.