Recombinant Human Peroxisomal membrane protein PEX14 (PEX14)

Uniprot Id

O75381

Target Species

Human

Target Name

PEX14

Target Full Name

Peroxisomal membrane protein PEX14

Target Function

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.

Target Involvement

Peroxisome biogenesis disorder complementation group K (PBD-CGK); Peroxisome biogenesis disorder 13A (PBD13A)

Target Subcellular Location

Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Peroxin-14 family

Target Synonyms

dJ734G22.2; NAPP2 ; NF E2 associated polypeptide 2 ; Peroxin 14 ; Peroxin-14; Peroxisomal biogenesis factor 14; Peroxisomal membrane anchor protein PEX14; Peroxisomal membrane anchor protein Pex14p; Peroxisomal membrane protein PEX14; pex14; PEX14_HUMAN; Pex14p; PTS1 receptor docking protein; PTS1 receptor-docking protein

Target Background

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.