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The recombinant Human PPARA was expressed with the amino acid range of 1-468. The expected molecular weight for the PPARA protein is calculated to be 56.2 kDa. This protein is generated in a baculovirus-based system. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of PPARA, making it easier to detect and purify the PPARA recombinant protein in the later stages of expression and purification.PPARA (Peroxisome proliferator-activated receptor alpha) is a nuclear receptor playing a crucial role in energy and lipid metabolism. Research primarily focuses on two major areas. Firstly, the role of PPARA in lipid metabolism regulation is widely studied. Researchers delve into the regulatory mechanisms of PPARA in fatty acid oxidation, activation of brown adipose tissue, cholesterol metabolism, providing new insights into the treatment of metabolic diseases like diabetes and hyperlipidemia. Secondly, the physiological functions of PPARA in tissues such as the liver and heart have attracted considerable attention. Researchers are attentive to PPARA's regulatory role in liver lipid metabolism, cardiac protection, and its involvement in metabolism-related inflammatory responses.
The recombinant Human PPARA was expressed with the amino acid range of 1-468. The expected molecular weight for the PPARA protein is calculated to be 56.2 kDa. This protein is generated in a baculovirus-based system. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of PPARA, making it easier to detect and purify the PPARA recombinant protein in the later stages of expression and purification.PPARA (Peroxisome proliferator-activated receptor alpha) is a nuclear receptor playing a crucial role in energy and lipid metabolism. Research primarily focuses on two major areas. Firstly, the role of PPARA in lipid metabolism regulation is widely studied. Researchers delve into the regulatory mechanisms of PPARA in fatty acid oxidation, activation of brown adipose tissue, cholesterol metabolism, providing new insights into the treatment of metabolic diseases like diabetes and hyperlipidemia. Secondly, the physiological functions of PPARA in tissues such as the liver and heart have attracted considerable attention. Researchers are attentive to PPARA’s regulatory role in liver lipid metabolism, cardiac protection, and its involvement in metabolism-related inflammatory responses.
| Cat.No | ACP02620 | Target Name | PPARA |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 1-468aa | Mol Weight | 56.2 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q07869 |
|---|
Uniprot Id
Q07869
Target Species
Human
Target Name
PPARA
Target Full Name
Peroxisome proliferator-activated receptor alpha
Target Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Target Subcellular Location
Nucleus.
Target Protein Families
Nuclear hormone receptor family, NR1 subfamily
Target Tissue Specificity
Skeletal muscle, liver, heart and kidney. Expressed in monocytes.
Target Research Area
Cancer
Target Synonyms
hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferative activated receptor alpha; Peroxisome proliferator activated receptor alpha; Peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha; ppara; PPARA_HUMAN; PPARalpha
Target Background
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
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