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| Cat.No | ACP19466 | Target Name | PHACTR4 |
|---|---|---|---|
| Target Synonyms | Phactr4; PHAR4_HUMAN; Phosphatase and actin regulator 4; PRO2963 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-702 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IZ21 |
|---|
Uniprot Id
Q8IZ21
Target Species
Human
Target Name
PHACTR4
Target Full Name
Phosphatase and actin regulator 4
Target Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.
Target Subcellular Location
Cytoplasm. Cell projection, lamellipodium.
Target Protein Families
Phosphatase and actin regulator family
Target Synonyms
Phactr4; PHAR4_HUMAN; Phosphatase and actin regulator 4; PRO2963
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