Recombinant Human Phosphoglycerate kinase 2 (PGK2)

Uniprot Id

P07205

Target Species

Human

Target Name

PGK2

Target Full Name

Phosphoglycerate kinase 2

Target Function

Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Phosphoglycerate kinase family

Target Tissue Specificity

Mainly found in round spermatids. Localized on the principle piece in the sperm (at protein level). Testis-specific. Expression significantly decreased in the testis of elderly men.

Target Synonyms

dJ417L20.2; PGK 2; pgk2; PGK2_HUMAN; PGKB; PGKPS; Phosphoglycerate kinase 2; Phosphoglycerate kinase; Phosphoglycerate kinase autosomal pseudogene; Phosphoglycerate kinase testis specific; testis specific

Target Background

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1, 3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.