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| Cat.No | ACP05283 | Target Name | PGBD5 |
|---|---|---|---|
| Target Synonyms | PGBD5; PiggyBac transposable element-derived protein 5; PiggyBac domain-related protein 5; PiggyBac transposase 5 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-524 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N414 |
|---|
Uniprot Id
Q8N414
Target Species
Human
Target Name
PGBD5
Target Full Name
PiggyBac transposable element-derived protein 5
Target Function
Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene.
Target Involvement
Induces site-specific DNA rearrangements, including intrachromosomal deletions, as well as inversions, duplications and translocations, in rhabdoid tumors that share developmental origin with cells that normally express PGBD5, even though these tumors may not exhibit apparent widespread genomic instability. This activity recurrently targets regulatory elements and tumor suppressor genes and promotes cell transformation.
Target Subcellular Location
Nucleus.
Target Synonyms
PGBD5; PiggyBac transposable element-derived protein 5; PiggyBac domain-related protein 5; PiggyBac transposase 5
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