Recombinant Human Plastin-1 (PLS1)

Uniprot Id

Q14651

Target Species

Human

Target Name

PLS1

Target Full Name

Plastin-1

Target Function

Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.

Target Subcellular Location

Cytoplasm. Cell projection, stereocilium.

Target Tissue Specificity

In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.

Target Synonyms

PLS1; Plastin-1; Intestine-specific plastin; I-plastin

Target Background

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.