Recombinant Human Platelet-activating factor acetylhydrolase 2, cytoplasmic (PAFAH2)

Uniprot Id

Q99487

Target Species

Human

Target Name

PAFAH2

Target Full Name

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Target Function

Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position.

Target Subcellular Location

Cytoplasm. Membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor.

Target Protein Families

Serine esterase family

Target Tissue Specificity

Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex.

Target Synonyms

PAFAH2Platelet-activating factor acetylhydrolase 2; cytoplasmic; EC 3.1.1.47; Serine-dependent phospholipase A2; SD-PLA2; hSD-PLA2

Target Background

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.