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The recombinant Human PODXL was expressed with the amino acid range of 32-458. The calculated molecular weight for this PODXL protein is 48.2 kDa. The PODXL protein was expressed in e.coli. Fusion of the N-terminal 6xHis tag into the PODXL encoding gene fragment was conducted, allowing for easier detection and purification of the PODXL protein in subsequent stages.Human podocalyxin (PODXL) is a transmembrane glycoprotein that is mainly expressed in kidney podocytes, vascular endothelia, and hematopoietic cells. It is involved in various physiological processes, including cell adhesion, migration, and signaling. Its extracellular domain is implicated in interactions with other proteins, influencing cell morphology. In cancer research, PODXL is associated with tumor progression and metastasis. Understanding the functions of PODXL provides insights into developmental biology, kidney physiology, and cancer pathology.
The recombinant Human PODXL was expressed with the amino acid range of 32-458. The calculated molecular weight for this PODXL protein is 48.2 kDa. The PODXL protein was expressed in e.coli. Fusion of the N-terminal 6xHis tag into the PODXL encoding gene fragment was conducted, allowing for easier detection and purification of the PODXL protein in subsequent stages.Human podocalyxin (PODXL) is a transmembrane glycoprotein that is mainly expressed in kidney podocytes, vascular endothelia, and hematopoietic cells. It is involved in various physiological processes, including cell adhesion, migration, and signaling. Its extracellular domain is implicated in interactions with other proteins, influencing cell morphology. In cancer research, PODXL is associated with tumor progression and metastasis. Understanding the functions of PODXL provides insights into developmental biology, kidney physiology, and cancer pathology.
| Cat.No | ACP02842 | Target Name | PODXL |
|---|---|---|---|
| Target Synonyms | GCTM-2 antigen; Gp2; Gp200; MGC138240; PC; PCLP; PCLP-1; PCLP1; Pcx; Podocalyxin; Podocalyxin like; Podocalyxin like protein; Podocalyxin-like protein 1; Podxl; PODXL_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 32-458aa |
| Mol Weight | 48.2kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00592 |
|---|
Uniprot Id
O00592
Target Species
Human
Target Name
PODXL
Target Full Name
Podocalyxin
Target Function
Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Target Subcellular Location
Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane; Single-pass type I membrane protein.
Target Protein Families
Podocalyxin family
Target Tissue Specificity
Glomerular epithelium cell (podocyte).
Target Research Area
Cancer
Target Synonyms
GCTM-2 antigen; Gp2; Gp200; MGC138240; PC; PCLP; PCLP-1; PCLP1; Pcx; Podocalyxin; Podocalyxin like; Podocalyxin like protein; Podocalyxin-like protein 1; Podxl; PODXL_HUMAN
Target Background
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
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