Recombinant Human Potassium channel subfamily K member 6 (KCNK6), Truncated

Uniprot Id

Q9Y257

Target Species

Human

Target Name

KCNK6

Target Full Name

Potassium channel subfamily K member 6

Target Function

Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Two pore domain potassium channel (TC 1.A.1.8) family

Target Tissue Specificity

Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression

Target Synonyms

KCNK6; TOSS; TWIK2; Potassium channel subfamily K member 6; Inward rectifying potassium channel protein TWIK-2; TWIK-originated similarity sequence

Target Background

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.