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| Cat.No | ACP05596 | Target Name | HCN4 |
|---|---|---|---|
| Target Synonyms | HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y3Q4 |
|---|
Uniprot Id
Q9Y3Q4
Target Species
Human
Target Name
HCN4
Target Full Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Target Function
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
Target Involvement
Sick sinus syndrome 2 (SSS2); Brugada syndrome 8 (BRGDA8)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Potassium channel HCN family
Target Tissue Specificity
Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus.
Target Synonyms
HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
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