Recombinant Human Potassium-transporting ATPase alpha chain 1 (ATP4A), Truncated

Uniprot Id

P20648

Target Species

Human

Target Name

ATP4A

Target Full Name

Potassium-transporting ATPase alpha chain 1

Target Function

The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state

Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily

Target Tissue Specificity

Expressed in gastric parietal cells (at protein level).

Target Research Area

Others

Target Synonyms

Atp4a; ATP4A_HUMAN; ATP6A; ATPase H+/K+ exchanging alpha polypeptide; ATPase H+/K+ transporting alpha polypeptide; Gastric H K ATPase alpha subunit; Gastric H K ATPase catalytic subunit; Gastric H(+)/K(+) ATPase subunit alpha; Gastric H+/K+ ATPase alpha subunit; Gastric hydrogen potassium ATPase; H(+) K(+) ATPase alpha subunit ; Potassium-transporting ATPase alpha chain 1; Proton pump