Recombinant Human Potassium voltage-gated channel subfamily H member 7 (KCNH7), Truncated

Uniprot Id

Q9NS40

Target Species

Human

Target Name

KCNH7

Target Full Name

Voltage-gated inwardly rectifying potassium channel KCNH7

Target Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.3/KCNH7 sub-subfamily

Target Tissue Specificity

Expressed in prolactin-secreting adenomas.

Target Synonyms

KCNH7; ERG3Potassium voltage-gated channel subfamily H member 7; Ether-a-go-go-related gene potassium channel 3; ERG-3; Eag-related protein 3; Ether-a-go-go-related protein 3; hERG-3; Voltage-gated potassium channel subunit Kv11.3

Target Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms.