Recombinant Human POU domain, class 4, transcription factor 2 (POU4F2)

Cat.No	ACP05240	Target Name	POU4F2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-265aa	Mol Weight	36.0 kDa
Protein Length	Full Length of Isoform 2	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05240

Target Name

POU4F2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-265aa

Mol Weight

36.0 kDa

Protein Length

Full Length of Isoform 2

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q12837

Background Information

Uniprot Id

Q12837
Target Species

Human
Target Name

POU4F2
Target Full Name

POU domain, class 4, transcription factor 2
Target Function

Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation
Target Subcellular Location

Nucleus. Nucleus speckle. Cytoplasm.
Target Protein Families

POU transcription factor family, Class-4 subfamily
Target Tissue Specificity

Expressed in the brain. Expressed in the ganglion cell layer of the retina.
Target Research Area

Others
Target Synonyms

Brain specific homeobox/POU domain protein 3B; Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3B; BRN3.2; BRN3B; Brn3b POU domain transcription factor; class 4; PO4F2_HUMAN; POU class 4 homeobox 2; POU domain; POU domain class 4 transcription factor 2; POU domain protein; POU4F2; transcription factor 2

Recombinant Human POU domain, class 4, transcription factor 2 (POU4F2)

Specifications

Immunogen Information

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