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Recombinant Human Pre-mRNA 3′-end-processing factor FIP1 (FIP1L1)

ACP16451

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Specifications

Cat.No	ACP16451	Target Name	FIP1L1
Target Synonyms	FIP1L1; FIP1; RHEPre-mRNA 3'-end-processing factor FIP1; hFip1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-594
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6UN15

Background Information

Uniprot Id

Q6UN15
Target Species

Human
Target Name

FIP1L1
Target Full Name

Pre-mRNA 3'-end-processing factor FIP1
Target Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.
Target Involvement

A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
Target Subcellular Location

Nucleus.
Target Protein Families

FIP1 family
Target Synonyms

FIP1L1; FIP1; RHEPre-mRNA 3'-end-processing factor FIP1; hFip1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia

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Recombinant Human Pre-mRNA 3′-end-processing factor FIP1 (FIP1L1)

Specifications

Immunogen Information

Inquire Recombinant Human Pre-mRNA 3′-end-processing factor FIP1 (FIP1L1) Now

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