Recombinant Human Pro-FMRFamide-related neuropeptide FF (NPFF), Truncated

Uniprot Id

O15130

Target Species

Human

Target Name

NPFF

Target Full Name

Pro-FMRFamide-related neuropeptide FF

Target Function

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.

Target Subcellular Location

Secreted.

Target Protein Families

FARP (FMRFamide related peptide) family

Target Research Area

Neuroscience

Target Synonyms

NPFF; Pro-FMRFamide-related neuropeptide FF; FMRFamide-related peptides) [Cleaved into: Neuropeptide SF; NPSF); Neuropeptide FF; NPFF); Neuropeptide AF; NPAF)]

Target Background

This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.