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The recombinant Human NRG3 was expressed with the amino acid range of 1-360. The expected molecular weight for the NRG3 protein is calculated to be 53.8 kDa. Expression of this NRG3 protein is conducted in e.coli. The NRG3 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant NRG3 protein in following stages of expression and purification.The human pro-neuregulin-3 is a membrane-bound isoform of the neuregulin-3 (NRG3) protein. Neuregulins are signaling proteins involved in neural development and function. NRG3 plays a crucial role in neuronal and glial differentiation, as well as in the development of the nervous system. As a membrane-bound isoform, pro-neuregulin-3 likely functions in cell-cell communication by interacting with its receptors on neighboring cells. Research areas related to pro-neuregulin-3 include neurobiology, neurodevelopmental disorders, and potential implications in conditions affecting the nervous system. Understanding its role may provide insights into the molecular mechanisms underlying neural development and contribute to therapeutic strategies for neurological disorders.
The recombinant Human NRG3 was expressed with the amino acid range of 1-360. The expected molecular weight for the NRG3 protein is calculated to be 53.8 kDa. Expression of this NRG3 protein is conducted in e.coli. The NRG3 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant NRG3 protein in following stages of expression and purification.The human pro-neuregulin-3 is a membrane-bound isoform of the neuregulin-3 (NRG3) protein. Neuregulins are signaling proteins involved in neural development and function. NRG3 plays a crucial role in neuronal and glial differentiation, as well as in the development of the nervous system. As a membrane-bound isoform, pro-neuregulin-3 likely functions in cell-cell communication by interacting with its receptors on neighboring cells. Research areas related to pro-neuregulin-3 include neurobiology, neurodevelopmental disorders, and potential implications in conditions affecting the nervous system. Understanding its role may provide insights into the molecular mechanisms underlying neural development and contribute to therapeutic strategies for neurological disorders.
| Cat.No | ACP03804 | Target Name | NRG3 |
|---|---|---|---|
| Target Synonyms | HRG3; Neuregulin 3; Neuregulin 3 like polypeptide; Neuregulin-3; Neuregulin3; NRG-3; Nrg3; NRG3_HUMAN; Pro neuregulin 3; pro NRG3; Pro-NRG3 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-360aa |
| Mol Weight | 53.8kDa | Protein Length | Extracellular Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P56975 |
|---|
Uniprot Id
P56975
Target Species
Human
Target Name
NRG3
Target Full Name
Pro-neuregulin-3, membrane-bound isoform
Target Function
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Target Subcellular Location
[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-3]: Secreted.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
Target Protein Families
Neuregulin family
Target Tissue Specificity
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, col
Target Research Area
Cancer
Target Synonyms
HRG3; Neuregulin 3; Neuregulin 3 like polypeptide; Neuregulin-3; Neuregulin3; NRG-3; Nrg3; NRG3_HUMAN; Pro neuregulin 3; pro NRG3; Pro-NRG3
Target Background
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
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