Recombinant Human Pro-neuropeptide Y (NPY)

Uniprot Id

P01303

Target Species

Human

Target Name

NPY

Target Full Name

Pro-neuropeptide Y

Target Function

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Target Subcellular Location

Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.

Target Protein Families

NPY family

Target Tissue Specificity

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Target Synonyms

C-flanking peptide of NPY; CPON; Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; NPY_HUMAN; Pro neuropeptide Y; PYY 4; PYY4; Y Neuropeptide

Target Background

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.