Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7)

Uniprot Id

Q9BT30

Target Species

Human

Target Name

ALKBH7

Target Full Name

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

Target Function

May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

AlkB family

Target Tissue Specificity

Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.

Target Synonyms

ALKBH7; ABH7; SPATA11; UNQ6002/PRO34564; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7; mitochondrial; EC 1.14.11.-; Alkylated DNA repair protein alkB homolog 7; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11

Target Background

Predicted to enable dioxygenase activity and metal ion binding activity. Involved in cellular response to DNA damage stimulus and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix.