Recombinant Human Probable ATP-dependent RNA helicase DDX31 (DDX31), Truncated

Uniprot Id

Q9H8H2

Target Species

Human

Target Name

DDX31

Target Full Name

ATP-dependent DNA helicase DDX31

Target Function

Probable ATP-dependent RNA helicase. Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1.

Target Subcellular Location

Nucleus, nucleolus.

Target Protein Families

DEAD box helicase family, DDX31/DBP7 subfamily

Target Tissue Specificity

Weakly or undetectably expressed in normal organs. Up-regulated in renal cell carcinoma.

Target Synonyms

DDX31Probable ATP-dependent RNA helicase DDX31; EC 3.6.4.13; DEAD box protein 31; Helicain

Target Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.