Recombinant Human Probable ATP-dependent RNA helicase DDX47 (DDX47)

Uniprot Id

Q9H0S4

Target Species

Human

Target Name

DDX47

Target Full Name

Probable ATP-dependent RNA helicase DDX47

Target Function

Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.

Target Subcellular Location

Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.

Target Protein Families

DEAD box helicase family, DDX47/RRP3 subfamily

Target Tissue Specificity

Expressed in skin, lung and breast. Also expressed in the brain.

Target Synonyms

DDX47; DDX47_HUMAN; DEAD (Asp Glu Ala Asp) box polypeptide 47; DEAD box helicase 47; DEAD box protein 47; DKFZp564O176 ; E4 DBP; FLJ30012 ; HGNC:18682; HQ0256 ; MSTP162 ; Probable ATP dependent RNA helicase DDX47; Probable ATP-dependent RNA helicase DDX47

Target Background

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.