Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 (TRIM8)

Uniprot Id

Q9BZR9

Target Species

Human

Target Name

TRIM8

Target Full Name

E3 ubiquitin-protein ligase TRIM8

Target Function

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

TRIM/RBCC family

Target Tissue Specificity

Widely expressed.

Target Synonyms

AA408830; BB006755; GERP; Glioblastoma-expressed RING finger protein; Lioblastoma expressed ring finger protein; Probable E3 ubiquitin-protein ligase TRIM8; RING finger protein 27; RNF27; RP11-47A8.4; TRIM8; TRIM8_HUMAN; Tripartite motif containing 8; Tripartite motif protein TRIM8; Tripartite motif-containing protein 8