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| Cat.No | ACP05389 | Target Name | ATP8B3 |
|---|---|---|---|
| Target Synonyms | ATP8B3; ATP1K; FOS37502_2Phospholipid-transporting ATPase IK; EC 7.6.2.1; ATPase class I type 8B member 3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60423 |
|---|
Uniprot Id
O60423
Target Species
Human
Target Name
ATP8B3
Target Full Name
Phospholipid-transporting ATPase IK
Target Function
P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida.
Target Subcellular Location
Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Target Tissue Specificity
Isoform 3 was only detected in testis.
Target Synonyms
ATP8B3; ATP1K; FOS37502_2Phospholipid-transporting ATPase IK; EC 7.6.2.1; ATPase class I type 8B member 3
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