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| Cat.No | ACP20979 | Target Name | TRUB2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-331 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95900 |
|---|
Uniprot Id
O95900
Target Species
Human
Target Name
TRUB2
Target Full Name
Pseudouridylate synthase TRUB2, mitochondrial
Target Function
Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Pseudouridine synthase TruB family
Target Synonyms
CLONE24922; OTTHUMP00000022257; Probable tRNA pseudouridine synthase 2; RP11 339B21.1; TRUB 2; TruB pseudouridine (psi) synthase homolog 2; TruB pseudouridine (psi) synthase homolog2 (E. coli); trub2; TRUB2_HUMAN
Target Background
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).
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