Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein (BTC)

Uniprot Id

P35070

Target Species

Human

Target Name

BTC

Target Full Name

Probetacellulin

Target Function

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Target Subcellular Location

[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

Target Research Area

Signal Transduction

Target Synonyms

BTCProbetacellulin [Cleaved into: Betacellulin; BTC)]

Target Background

This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.