Recombinant Human Prolactin regulatory element-binding protein (PREB), Truncated

Uniprot Id

Q9HCU5

Target Species

Human

Target Name

PREB

Target Full Name

Guanine nucleotide-exchange factor SEC12

Target Function

Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus.

Target Tissue Specificity

Ubiquitous.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Mammalian guanine nucleotide exchange factor mSec12; Preb; PREB_HUMAN; Prolactin regulatory binding element protein; Prolactin regulatory element binding; Prolactin regulatory element binding protein; Prolactin regulatory element-binding protein; SEC12

Target Background

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.