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| Cat.No | ACP13557 | Target Name | PRCC |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-491 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92733 |
|---|
Uniprot Id
Q92733
Target Species
Human
Target Name
PRCC
Target Full Name
Proline-rich protein PRCC
Target Function
May regulate cell cycle progression through interaction with MAD2L2.
Target Involvement
A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Ubiquitous in fetal and adult tissues.
Target Synonyms
Papillary renal cell carcinoma (Translocation associated); isoform CRA_b ; Papillary renal cell carcinoma translocation-associated gene protein; PRCC; PRCC_HUMAN; Proline rich protein PRCC; Proline-rich protein PRCC; RCCP1; TPRC
Target Background
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.
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