Recombinant Human Prorelaxin H1 (RLN1)

Uniprot Id

P04808

Target Species

Human

Target Name

RLN1

Target Full Name

Prorelaxin H1

Target Function

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

Target Subcellular Location

Secreted.

Target Protein Families

Insulin family

Target Tissue Specificity

Prostate. Not expressed in placenta, decidua or ovary.

Target Synonyms

H1; H1RLX; Preprorelaxin H1; Prorelaxin; Prorelaxin H1; REL1_HUMAN; Relaxin A chain; Relaxin H1; RLN 1; Rln1; RLXH1

Target Background

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin.