Recombinant Human Proteasome activator complex subunit 4 (PSME4), Truncated

Uniprot Id

Q14997

Target Species

Human

Target Name

PSME4

Target Full Name

Proteasome activator complex subunit 4

Target Function

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Target Subcellular Location

Cytoplasm, cytosol. Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).

Target Protein Families

BLM10 family

Target Synonyms

KIAA0077; PA200; Proteasome Activator 200 kDa; Proteasome activator complex subunit 4; Proteasome activator PA200; PSME 4; psme4; PSME4_HUMAN

Target Background

Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in nucleoplasm.