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| Cat.No | ACP11724 | Target Name | INTS13 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-706 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NVM9 |
|---|
Uniprot Id
Q9NVM9
Target Species
Human
Target Name
INTS13
Target Full Name
Integrator complex subunit 13
Target Function
Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
Asunder family
Target Tissue Specificity
Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.
Target Synonyms
asun; ASUN_HUMAN; Cell cycle regulator Mat89Bb homolog; Chromosome 12 open reading frame 11; FLJ10630; FLJ10637; Germ cell tumor 1; NET48; Protein asunder homolog; Sarcoma antigen NY SAR 95; Sarcoma antigen NY-SAR-95
Target Background
Involved in regulation of mitotic cell cycle. Acts upstream of or within centrosome localization; mitotic spindle organization; and protein localization to nuclear envelope. Located in cytoplasm and nuclear body.
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