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| Cat.No | ACP13136 | Target Name | ATOH7 |
|---|---|---|---|
| Target Synonyms | ATOH7; ATOH7_HUMAN; Atonal homolog 7 (Drosophila); Atonal Homolog 7; bHLHa13; Class A basic helix-loop-helix protein 13; hATH5; Helix-loop-helix protein hATH-5; Math5; Protein atonal homolog 7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-152 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N100 |
|---|
Uniprot Id
Q8N100
Target Species
Human
Target Name
ATOH7
Target Full Name
Transcription factor ATOH7
Target Function
Transcription factor that positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract. Required for retinal circadian rhythm photoentrainment.
Target Involvement
Persistent hyperplastic primary vitreous, autosomal recessive (PHPVAR)
Target Subcellular Location
Nucleus.
Target Synonyms
ATOH7; ATOH7_HUMAN; Atonal homolog 7 (Drosophila); Atonal Homolog 7; bHLHa13; Class A basic helix-loop-helix protein 13; hATH5; Helix-loop-helix protein hATH-5; Math5; Protein atonal homolog 7
Target Background
This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment.
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