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| Cat.No | ACP04380 | Target Name | FAM49B |
|---|---|---|---|
| Target Synonyms | BM 009; FA49B_HUMAN; Fam49b; Family with sequence similarity 49; member B; L1; Protein FAM49B | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-324aa |
| Mol Weight | 52.7kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NUQ9 |
|---|
Uniprot Id
Q9NUQ9
Target Species
Human
Target Name
CYRIB
Target Full Name
CYFIP-related Rac1 interactor B
Target Function
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress.
Target Subcellular Location
Membrane; Lipid-anchor. Mitochondrion.
Target Protein Families
FAM49 family
Target Research Area
Cell Biology
Target Synonyms
BM 009; FA49B_HUMAN; Fam49b; Family with sequence similarity 49; member B; L1; Protein FAM49B
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