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| Cat.No | ACP06336 | Target Name | MPIG6B |
|---|---|---|---|
| Target Synonyms | MPIG6B; C6orf25; G6B; G6B-B; Megakaryocyte and platelet inhibitory receptor G6b; Protein G6b | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95866 |
|---|
Uniprot Id
O95866
Target Species
Human
Target Name
MPIG6B
Target Full Name
Megakaryocyte and platelet inhibitory receptor G6b
Target Function
Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner.; Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B
Target Involvement
Thrombocytopenia, anemia, and myelofibrosis (THAMY)
Target Subcellular Location
[Isoform E]: Endoplasmic reticulum. Golgi apparatus.; [Isoform D]: Endoplasmic reticulum. Golgi apparatus.; [Isoform B]: Cell membrane; Single-pass type I membrane protein.; [Isoform A]: Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell l
Target Synonyms
MPIG6B; C6orf25; G6B; G6B-B; Megakaryocyte and platelet inhibitory receptor G6b; Protein G6b
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