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| Cat.No | ACP21630 | Target Name | AREL1 |
|---|---|---|---|
| Target Synonyms | AREL1; KIAA0317Apoptosis-resistant E3 ubiquitin protein ligase 1; EC 2.3.2.26; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15033 |
|---|
Uniprot Id
O15033
Target Species
Human
Target Name
AREL1
Target Full Name
Apoptosis-resistant E3 ubiquitin protein ligase 1
Target Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome.
Target Subcellular Location
Cytoplasm, cytosol.
Target Synonyms
AREL1; KIAA0317Apoptosis-resistant E3 ubiquitin protein ligase 1; EC 2.3.2.26; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1
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