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| Cat.No | ACP06059 | Target Name | LMBR1L |
|---|---|---|---|
| Target Synonyms | LMBR1L; KIAA1174; LIMR; UNQ458/PRO783Protein LMBR1L; Limb region 1 protein homolog-like; Lipocalin-1-interacting membrane receptor; LIMR | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6UX01 |
|---|
Uniprot Id
Q6UX01
Target Species
Human
Target Name
LMBR1L
Target Full Name
Protein LMBR1L
Target Function
Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway. In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels. Acts as a LCN1 receptor and can mediate its endocytosis.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
LIMR family
Target Tissue Specificity
Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate.
Target Synonyms
LMBR1L; KIAA1174; LIMR; UNQ458/PRO783Protein LMBR1L; Limb region 1 protein homolog-like; Lipocalin-1-interacting membrane receptor; LIMR
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