Recombinant Human Protein-lysine 6-oxidase (LOX)

Uniprot Id

P28300

Target Species

Human

Target Name

LOX

Target Full Name

Protein-lysine 6-oxidase

Target Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.

Target Involvement

Aortic aneurysm, familial thoracic 10 (AAT10)

Target Subcellular Location

Secreted. Secreted, extracellular space.

Target Protein Families

Lysyl oxidase family

Target Tissue Specificity

Heart, placenta, skeletal muscle, kidney, lung and pancreas.

Target Research Area

Cardiovascular, Signal Transduction

Target Synonyms

lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase

Target Background

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.