Recombinant Human Protein-methionine sulfoxide oxidase MICAL1 (MICAL1), Truncated

Cat.No	ACP13012	Target Name	MICAL1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13012

Target Name

MICAL1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8TDZ2

Background Information

Uniprot Id

Q8TDZ2
Target Species

Human
Target Name

MICAL1
Target Full Name

[F-actin]-monooxygenase MICAL1
Target Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Midbody.
Target Protein Families

Mical family
Target Tissue Specificity

Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
Target Synonyms

CasL interacting molecule; DKFZp434B1517; FLJ11937; FLJ21739; MICA1_HUMAN; MICAL 1; MICAL; MICAL1; microtubule associated monoxygenase; calponin and LIM domain containing 1; Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL; OTTHUMP00000016969
Target Background

This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants.

Recombinant Human Protein-methionine sulfoxide oxidase MICAL1 (MICAL1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Protein-methionine sulfoxide oxidase MICAL1 (MICAL1), Truncated Now

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