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| Cat.No | ACP12348 | Target Name | PAXX |
|---|---|---|---|
| Target Synonyms | C9orf142; Chromosome 9 open reading frame 142 ; CI142_HUMAN; PAXX; Uncharacterized protein C9orf142; XLS | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-204 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BUH6 |
|---|
Uniprot Id
Q9BUH6
Target Species
Human
Target Name
PAXX
Target Full Name
Protein PAXX
Target Function
Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination. May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Involved in NHEJ by promoting the ligation of blunt-ended DNA ends. Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair. Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism
Target Subcellular Location
Nucleus. Chromosome.; Cytoplasm.
Target Synonyms
C9orf142; Chromosome 9 open reading frame 142 ; CI142_HUMAN; PAXX; Uncharacterized protein C9orf142; XLS
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