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| Cat.No | ACP11263 | Target Name | RMND5A |
|---|---|---|---|
| Target Synonyms | RMND5A; E3 ubiquitin-protein transferase RMND5A; EC 2.3.2.27; P44CTLH; Protein RMD5 homolog A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-391 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H871 |
|---|
Uniprot Id
Q9H871
Target Species
Human
Target Name
RMND5A
Target Full Name
E3 ubiquitin-protein transferase RMND5A
Target Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Target Subcellular Location
Nucleus, nucleoplasm. Cytoplasm.
Target Research Area
Others
Target Synonyms
RMND5A; E3 ubiquitin-protein transferase RMND5A; EC 2.3.2.27; P44CTLH; Protein RMD5 homolog A
Target Background
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex.
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