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| Cat.No | ACP12622 | Target Name | RMND5B |
|---|---|---|---|
| Target Synonyms | RMND5B; UNQ2508/PRO5996; E3 ubiquitin-protein transferase RMND5B; EC 2.3.2.27; Protein RMD5 homolog B | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-393 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96G75 |
|---|
Uniprot Id
Q96G75
Target Species
Human
Target Name
RMND5B
Target Full Name
E3 ubiquitin-protein transferase RMND5B
Target Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Target Subcellular Location
Cytoplasm, cytosol.
Target Synonyms
RMND5B; UNQ2508/PRO5996; E3 ubiquitin-protein transferase RMND5B; EC 2.3.2.27; Protein RMD5 homolog B
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