Recombinant Human Protein RUFY3 (RUFY3)

Cat.No	ACP15728	Target Name	RUFY3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-469	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP15728

Target Name

RUFY3

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-469

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q7L099

Background Information

Uniprot Id

Q7L099
Target Species

Human
Target Name

RUFY3
Target Full Name

Protein RUFY3
Target Function

Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner.
Target Subcellular Location

Cytoplasm. Endomembrane system. Cell projection, invadopodium. Perikaryon. Cell projection. Cell projection, growth cone. Cell projection, filopodium. Cell projection, lamellipodium.
Target Tissue Specificity

Overexpressed in gastric cancer cells and tissues (at protein level).
Target Synonyms

Protein RUFY3; rap2 interacting protein x; Rap2 interacting protein x isoform 2; Rap2-interacting protein x; RIPx; Rpipx; Rufy3; RUFY3_HUMAN; RUN and FYVE domain containing 3; Singar; Singar1; Single axon regulated protein; single axon related 1; Single axon-regulated protein
Target Background

This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants.

Recombinant Human Protein RUFY3 (RUFY3)

Specifications

Immunogen Information

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