Recombinant Human Protein S100-A5 (S100A5)

Uniprot Id

P33763

Target Species

Human

Target Name

S100A5

Target Full Name

Protein S100-A5

Target Function

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.

Target Protein Families

S-100 family

Target Synonyms

Protein S-100D; Protein S100-A5; S100 calcium binding protein A5; S100 calcium-binding protein A5; S100a5; S100D; S100D9; S10A5_HUMAN

Target Background

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.