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| Cat.No | ACP19901 | Target Name | SHISA7 |
|---|---|---|---|
| Target Synonyms | SHISA7; Protein shisa-7; Cystine-knot AMPAR modulating protein of 59 kDa; CKAMP59; GABA(A) receptor auxiliary subunit Shisa7; Protein shisa-6-like | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A6NL88 |
|---|
Uniprot Id
A6NL88
Target Species
Human
Target Name
SHISA7
Target Full Name
Protein shisa-7
Target Function
Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses.
Target Subcellular Location
Cell junction, synapse, postsynaptic density membrane; Single-pass type I membrane protein.
Target Protein Families
Shisa family
Target Synonyms
SHISA7; Protein shisa-7; Cystine-knot AMPAR modulating protein of 59 kDa; CKAMP59; GABA(A) receptor auxiliary subunit Shisa7; Protein shisa-6-like
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