Recombinant Human Protein unc-13 homolog B (UNC13B), Truncated

Uniprot Id

O14795

Target Species

Human

Target Name

UNC13B

Target Full Name

Protein unc-13 homolog B

Target Function

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release.

Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse.

Target Protein Families

Unc-13 family

Target Tissue Specificity

Expressed in kidney cortical epithelial cells and brain.

Target Synonyms

hmunc13; MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B_HUMAN; unc-13 homolog B (C. elegans); UNC13; Unc13b; Unc13h2

Target Background

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.