Recombinant Human Protein unc-93 homolog B1 (UNC93B1), Truncated

Uniprot Id

Q9H1C4

Target Species

Human

Target Name

UNC93B1

Target Full Name

Protein unc-93 homolog B1

Target Function

Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.

Target Involvement

Herpes simplex encephalitis 1 (HSE1)

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome.

Target Protein Families

Unc-93 family

Target Tissue Specificity

Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.

Target Synonyms

UNC93B1; UNC93; UNC93B; Protein unc-93 homolog B1; Unc-93B1; hUNC93B1

Target Background

This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis.