Recombinant Human Protein Wnt-10b (WNT10B)

Uniprot Id

O00744

Target Species

Human

Target Name

WNT10B

Target Full Name

Protein Wnt-10b

Target Function

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

Target Involvement

Split-hand/foot malformation 6 (SHFM6); Tooth agenesis, selective, 8 (STHAG8)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted.

Target Protein Families

Wnt family

Target Tissue Specificity

Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

Target Synonyms

Protein Wnt-10b; Protein Wnt-12; SHFM6; wingless type MMTV integration site family; member 10B; WN10B_HUMAN; WNT 10B protein; WNT 12; Wnt10b; wnt12

Target Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.