Home Products Recombinant Human Putative E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)

Recombinant Human Putative E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)

ACP13611

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Specifications

Cat.No	ACP13611	Target Name	SH3RF2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-729	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8TEC5

Background Information

Uniprot Id

Q8TEC5
Target Species

Human
Target Name

SH3RF2
Target Full Name

E3 ubiquitin-protein ligase SH3RF2
Target Function

Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity.
Target Subcellular Location

Nucleus.
Target Protein Families

SH3RF family
Target Tissue Specificity

Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.
Target Synonyms

SH3RF2; POSH3; POSHER; PPP1R39; RNF158; E3 ubiquitin-protein ligase SH3RF2; EC 2.3.2.27; Heart protein phosphatase 1-binding protein; HEPP1; POSH-eliminating RING protein; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2

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Recombinant Human Putative E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)

Specifications

Immunogen Information

Inquire Recombinant Human Putative E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) Now

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