Recombinant Human Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1), Truncated

Uniprot Id

Q15042

Target Species

Human

Target Name

RAB3GAP1

Target Full Name

Rab3 GTPase-activating protein catalytic subunit

Target Function

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

Target Involvement

Warburg micro syndrome 1 (WARBM1)

Target Subcellular Location

Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.

Target Protein Families

Rab3-GAP catalytic subunit family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

DKFZp434A012; KIAA0066; P130; Rab3 GAP; Rab3 GAP p130; RAB3 GTPase activating protein 130 kDa subunit; Rab3 GTPase activating protein catalytic subunit; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130; RAB3GAP; rab3gap1; RAB3GAP130; RB3GP_HUMAN; WARBM1

Target Background

This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.