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| Cat.No | ACP10844 | Target Name | ANKFY1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9P2R3 |
|---|
Uniprot Id
Q9P2R3
Target Species
Human
Target Name
ANKFY1
Target Full Name
Rabankyrin-5
Target Function
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport
Target Subcellular Location
Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome.
Target Tissue Specificity
High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain.
Target Synonyms
ANFY1_HUMAN; Ankfy1; ANKHZN; ankyrin repeat and FYVE domain containing 1; ankyrin repeat and FYVE domain containing protein 1; Ankyrin repeat and FYVE domain-containing protein 1; ankyrin repeat hooked to zinc finger motif; Ankyrin repeats hooked to a zinc finger motif; BTBD23; DKFZp686M19106; KIAA1255; Rabankyrin 5; ZFYVE14
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