Recombinant Human RAD52 motif-containing protein 1 (RDM1)

Uniprot Id

Q8NG50

Target Species

Human

Target Name

RDM1

Target Full Name

RAD52 motif-containing protein 1

Target Function

May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA.

Target Subcellular Location

Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Isoform 3 and isoform 10 are predominantly nuclear and nucleolar. After treatment with proteasomal inhibitors and mild heat-shock stress, isoform 1, isoform 3, isoform 5, isoform 7, isoform 8 and isoform 10 are relocalized to the nucleolus as dot-like or irregular subnuclear structures. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Isoform 3, but not isoform 1 and isoform 5, is relocalized in nucleolar caps during transcriptional arrest.; [Isoform 1]: Cytoplasm. Nucleus, PML body. Nucleus, Cajal body. Note=Isoform 1 is predominantly cytoplasmic. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress.

Target Tissue Specificity

Expressed in testis.

Target Synonyms

MGC33977; RAD52 homolog B; RAD52 motif 1; RAD52 motif containing 1; RAD52 motif-containing protein 1; RAD52B; RDM1; RDM1_HUMAN

Target Background

This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported.